                         SEQUENCE LISTING

<110>  IPSEN PHARMA S.A.S.
       DONG, Zheng  Xin
       SHEN, Yeelana
       DeOLIVEIRA, Daniel B.
 
<120>  Truncated Analogues of Glucose-Dependent Insulinotropic 
       Polypeptide

<130>  198P2/PCT2

<150>  61/188,192
<151>  2008-08-07

<150>  61/200,628
<151>  2008-12-02

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  2

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  3
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid

<400>  3

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  4
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  4

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  5
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  modified with N-propylsuccinimide (Psu)

<400>  5

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Cys Thr Gln 
        35      


<210>  6
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with N-propylsuccinimide (Psu)

<400>  6

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Cys Ile Thr Gln 
        35      


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with N-propylsuccinimide (Psu)

<400>  7

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys Cys 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  modified with N-propylsuccinimide (Psu)

<400>  8

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Cys Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  modified with N-propylsuccinimide (Psu)

<400>  9

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Cys Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  10
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with N-propylsuccinimide (Psu)

<400>  10

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Cys Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  modified with N-propylsuccinimide (Psu)

<400>  11

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Cys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  12
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<400>  12

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Cys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<400>  13

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  modified with N-propylsuccinimide (Psu)

<400>  14

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Cys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<400>  15

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  16

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  17

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  18
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)8-C(O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  18

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)4-CH3)

<400>  19

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  20
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)4-CH3)

<400>  20

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  21
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)4-C(O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)4-CH3)

<400>  21

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  22
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  22

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Xaa Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  23

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Xaa Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  24
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)8-C(O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  24

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Xaa Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-hexylsuccinimide (Hsu)

<400>  25

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  26
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-hexylsuccinimide (Hsu)

<400>  26

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  27
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = beta-(2-naphthyl)alanine (2Nal)

<400>  27

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  28
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  28

Xaa Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His 
1               5                   10                  15      


Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn 
            20                  25                  30          


Asp Trp Lys His Asn Ile Thr Gln 
        35                  40  


<210>  29
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  29

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln Gln 
        35          


<210>  30
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  AMIDATION

<400>  30

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn 
            20                  25              


<210>  31
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  31

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25  


<210>  32
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<400>  32

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys 
            20                  25                  30          


His Asn Ile Thr Gln 
        35          


<210>  33
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<400>  33

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys 
            20                  25                  30          


His Asn Ile Thr Gln 
        35          


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  34

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  35
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  AMIDATION

<400>  35

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25      


<210>  36
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  AMIDATION

<400>  36

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25      


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  37

Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  38
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  38

Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  39
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  39

Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  40
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<400>  40

Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val Asn 
1               5                   10                  15      


Trp Leu Leu Ala Gln Lys Gly Lys Cys Asn Asp Trp Lys His Asn Ile 
            20                  25                  30          


Thr Gln 
        


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  41

Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val 
1               5                   10                  15      


Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His Asn 
            20                  25                  30          


Ile Thr Gln 
        35  


<210>  42
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with cyclohexyl carboxylic acid (Chc)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  modified with N-propylsuccinimide (Psu)

<400>  42

Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val 
1               5                   10                  15      


Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His Asn 
            20                  25                  30          


Ile Thr Gln 
        35  


<210>  43
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)4-C(O)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  modified with N-propylsuccinimide (Psu)

<400>  43

Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val 
1               5                   10                  15      


Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His Asn 
            20                  25                  30          


Ile Thr Gln 
        35  


<210>  44
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  44

Xaa Xaa Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  45
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = norleucine (Nle)

<400>  45

Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  46
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  46

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  47
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  47

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  48
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  48

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  49
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  49

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40          


<210>  50
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  50

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


